Magnesium L-Threonate, 90 capsules

Product detailed description

Dr. Mercola Magnesium L-Threonate, a highly effective form of magnesium valued for its high absorbability and utilization in the brain and for cells in the body. Magnesium threonate helps synaptic plasticity (related to learning, memory and cognitive function), and according to research, it increases the magnesium content in the brain by about 15%, where other forms of magnesium have difficulty reaching. It also plays a role in the process of reducing brain aging.

Pay attention to the quality of the product, there is only one original!

Always look for the original logo on a product that truly contains the patented form of magnesium Magtein.

The patent is subject to strict licensing rules, and the license not only requires the logo to be included, but also requires the recommended dosage to be the same per capsule for all manufacturers.

Magnesium L-threonate can be purchased as a raw material in China, generally referred to as C8H14MgO10 98-99% powder - it is definitely not Magtein, but an imitation of it by Chinese producers. Since it is a 98-99% copy, the consistency and composition according to the patent, which has not yet been released, are not guaranteed and are purchased under pre-agreed conditions.

We're not saying that it's inherently bad, everyone can buy whatever they want, but you need to be careful and take a risk if you buy such a version.

Such a product should meet not only microbiology, but also raw material tests, meaning that it is really a magnesium threonate molecule in the stated concentration.

Why is magnesium important for our body?

Magnesium ranks 4^th as one of the most abundant minerals in the body. It is important for approximately 300 enzymatic reactions in the body. It is primarily found in bones. It is also important for many physiological functions.

Magnesium is the king of minerals, just as vitamin D is the king of vitamins.

Magnesium is responsible for the proper functioning of basic metabolic processes, including DNA synthesis, including replication, and muscle contraction. It plays a crucial role in energy production, what we call ATP (adenosine triphosphate) is actually Mg-ATP. We must not forget that most biological enzymes catalyze the stress response using magnesium.

Approved claims according to EFSA:

• It contributes to reducing fatigue and exhaustion.
• Contributes to electrolyte balance.
• Contributes to normal energy metabolism.
• It contributes to the normal functioning of the nervous system.
• Contributes to normal muscle function.
• Contributes to normal protein synthesis.
• It contributes to normal mental activity.
• It contributes to maintaining normal bone health.
• Magnesium contributes to the maintenance of normal teeth.
• It participates in the process of cell division.

What should you pay attention to when consuming food?

Let's not forget that from a diet rich in Mg2+, about 30-40% is absorbed. So at 350 mg, the utilization will be approximately 105 - 140 mg (5 mmol Mg2+).

Examples of foods particularly rich in magnesium include (in order of magnesium content):

Foods (100 grams) magnesium content (mg):

• Seaweed, agar - 770 mg
• Coriander leaf (spice) - 694 mg
• Pumpkin seeds, dried - 535 mg
• Cocoa, dry powder, unsweetened - 499 mg
• Basil - 422 mg
• Cumin seeds (spice) - 386 mg
• Brazil nuts, dried - 376 mg
• Parsley - 372 mg
• Almond butter - 303 mg
• Whey, sweet - 176 mg
• Leek - 156 mg
• Cabbage, raw - 88 mg
• Spinach - 79 mg

I prefer the above list of foods and deliberately do not list problematic sources, which in many cases have an antagonistic effect (i.e. they contain an excess of minerals, phytates and other substances that, on the contrary, block magnesium or directly compete for transport systems in the body). It is important to prioritize organically produced foods - chemical fertilizers and pesticides do not contribute to optimal magnesium levels in the soil.

For maximum potential of the magnesium supplement, do not combine with milk and ideally without the foods on the list below. Magnesium interferes with phosphorus and potassium:

• A diet rich in phosphorus (meat and poultry, nuts, milk and legumes).
• A diet rich in potassium (avocado, bananas, oranges, potatoes, dairy products and eggs).

Some other sources rich in magnesium, as many of you suspect, may not be suitable from a health perspective, so there is no point in prioritizing them:

• coffee
• tea
• nuts
• legumes (phytates, phosphorus)
• whole grain cereals
• dairy products (problematic due to calcium content - antagonist)
• tofu (if you eat soy, look for the fermented version called nigari - magnesium chloride is used in the manufacturing process to coagulate the soy milk)
• cow's milk (calcium antagonist - interference at the muscle level during muscle contraction)

  

  What is the bioavailability of magnesium in our body?

  The Reference daily intake of magnesium ions is approximately 400 mg for an adult man and approximately 300 mg for a woman, which corresponds to an average of 15 mmol Mg2+.

  The main organ where magnesium is absorbed is the small intestine, but resorption also occurs in the large intestine (hereinafter GIT).

  From a diet rich in Mg2+, about 30-40% is absorbed. So at 350 mg, the utilization will be approximately 105 - 140 mg (5 mmol Mg2+).

  We must not forget that the level of ions absorbed from the GIT is greatly influenced by the composition of the diet, the hormonal balance in our body and, last but not least, the condition of the intestines (chronic intestinal inflammation and other problems have a negative effect).

  Some factors that increase the resorption of magnesium ions include:

  • Vitamin D (I don't mean the precursor cholecalciferol), but its active metabolite calcitriol, there's no need to write about the fact that almost all of us don't have optimal vitamin D levels (I recommend a biochemical test),
  • Parathyroid hormone (PTH) - participates in the conversion of the vitamin D precursor into the active form and thus indirectly helps the resorption of magnesium,
  • Growth hormone (HGH) - and its optimal levels,
  • Thyroxine - thyroid hormone (T4) - follicular cells need iodine to function properly (more is not better),
  • Vitamin B6 - pyridoxine (water-soluble, natural source: liver, pork, mackerel, eggs, spinach, avocado, nuts...).

  Some factors that reduce or block the resorption of magnesium ions:

  • A diet extra rich in fats and proteins (the reason is the formation of poorly absorbable complexes that prevent, among other things, reabsorption),
  • Diet high in Ca and Zn ions (pay attention to the balance of the diet, calcium and zinc compete with magnesium ions and transport systems; therefore, do not eat zinc together with magnesium, similarly do not eat vitamin C with selenium...),
  • Be careful with fiber (predominance of fiber, artificially supplied - psyllium, or natural, e.g. from vegetables; be careful not to follow some alternative nutritional styles too much), it also affects reabsorption
  • Aldosterone (the precursor is cholesterol, linked to Conn's syndrome, so be careful of an inappropriate lifestyle - stress, excess fat in the diet...).
  • Medication - be careful with the aminoglycoside antibiotic family (bactericidal antibiotics), some immunosuppressants, theophylline (respiratory treatment), amphotericin B (broad-spectrum antibiotic for mycoses), chemotherapeutics and antibiotics block magnesium transport in the kidneys (TALH) - especially with long-term use, digoxin (heart disease)...
  • Diabetes, alcoholism
  • Stress and high cortisol levels (magnesium, on the other hand, has a positive effect on cortisol levels and also stimulates the production of the DHEA precursor)

  The kidneys are responsible for regulating the excretion of magnesium ions. There are many factors that force the kidneys to excrete magnesium, one of the commercially known terms is metabolic acidosis.

  We must also not forget the fact that 60-70% of magnesium ions are excreted in the stool, so it depends on the condition of your intestines during magnesium resorption (negative effects - malabsorption syndrome, celiac disease, chronic intestinal inflammation, cystic fibrosis and others).

  Who is magnesium supplementation suitable for?

  

  If you suspect:

  • excessive stress factors (stress is involved in the excretion of magnesium from the body, high cortisol)
  • high blood pressure,
  • cramps in the lower limbs,
  • migraine, anxiety, irritability, depression,
  • heart disease (absolutely crucial for cardiovascular health, some doctors administer magnesium before certain surgeries),
  • unstable blood sugar levels,
  • insomnia
  • obesity problems
  • osteoporosis
  • diabetes (if you are insulin resistant, there is a problem with storing magnesium and it begins to be excreted in the urine; deficiency affects energy production - magnesium depletion precedes insulin resistance)
  • restless legs syndrome

  The Reference daily intake of magnesium ions is (which corresponds to an average of 15 mmol Mg2+):

  • for an adult man approx. 400 mg
  • for an adult woman approximately 300 mg.

  For men over 31 years of age, it is approximately 420 mg per day, for women approximately 320 mg per day.

Product benefits and what is magnesium L-threonate (Magtein)?

Magnesium L-threonate (MMFS-01 or Magtein™) is L-threonic acid combined with magnesium Mg2+.

Magtein is the only form that shows the ability to cross the blood-brain barrier.

Initial animal studies show that Magnesium L-threonate helps maintain neuronal cell health and increases neuronal plasticity. 

The last randomized, double-blind study (including placebo control) in humans was conducted in August 2016 (published in the Journal of Alzheimer’s Disease). Magnesium L-threonate (MMFS-01) has confirmed potential in improving cognitive function in older people.

Magnesium L-threonate shows promising potential in studies for:

• increased magnesium levels in the brain
• improvement of short-term and long-term memory
• as well as improving spatial perception and cognitive function.

Dr. Liu's tests show that magnesium L-threonate, after absorption, reaches the brain better than other forms of magnesium, and thus shows the best results.

Does old age really mean automatic memory loss?

Research shows that Magtein significantly helps synaptic plasticity (related to learning, memory, and cognitive function). According to current research, magnesium threonate increases the magnesium content in the brain by about 15%, where other forms of magnesium have difficulty reaching.

Different magnesium compounds vary significantly in their bioavailability and thus their ability to increase synaptic plasticity, which leads to increased memory and cognitive function.

Loss of synaptic plasticity in the brain is naturally related to aging (forgetfulness, fatigue, inability to react quickly, and more). According to scientists, using the right form of magnesium can greatly alleviate this process. Some data from animal models are even more optimistic. 

In 2015, a team led by Professor Guosong Liu (see below) studied patients aged 50 to 70 and concluded that magnesium L-threonate supplementation helped significantly slow the brain aging process.

Magnesium is simply crucial for the brain.

Magnesium contributes to the regulation of the formation of critical cell connections in the learning and memory center of the brain. Magnesium ions control electrical ion pathways in grey cells. The more signals they can transmit, the greater the connection and the better the memory. 

Comparison of the benefits of magnesium L-threonate (Magtein)

• does not contain fillers, dyes and preservatives (magnesium stearate), also non-GMO
• 2000 mg of Magtein in the reference daily intake (the maximum dose available in supplements on the market), 144 mg of magnesium with high bioavailability

  What forms of magnesium are used in supplements?

  • Magnesium glycinate - a chelated form of magnesium (normally 14% elemental magnesium, in Albion magnesia it is 18%) - a good alternative, however not as effective as L-threonate
  • Magnesium oxide - non-chelated form bound to an organic acid or fatty acid, contains approximately 60% elemental magnesium (absorbability approximately 4%)
  • Magnesium chloride/lactate - contains approximately 12% elemental magnesium, however it is more effective than magnesium oxide
  • Magnesium sulfate/hydroxide - a typical laxative, contains approximately 42% elemental magnesium
  • Magnesium carbonate - also used for stomach acid, contains approximately 29 - 45% elemental magnesium
  • Magnesium taurate - a combination of magnesium and amino acid (taurine) 
  • Magnesium citrate - contains approximately 12% elemental magnesium, similar to magnesium aspartate (both have an absorption rate of up to 70%)
  • Magnesium orotate - approx. 7% elemental magnesium per tablet
  • magnesium gluconate - approx. 6% elemental magnesium from the tablet (absorbability approx. 56%)

  It is necessary to distinguish between the elemental magnesium content in a tablet and the absorbability of this content for the body.

  

  Dr. Liu - helped develop the active ingredient Magtein™

  Professor Guosong Liu, M.D., Ph.D. is the president and founder of the Center for Learning and Memory, School of Medicine, Tsinghua University, Beijing, China, and an adjunct professor at the Center for Learning and Memory, University of Texas Austin.

  

  Dr. Liu spent 10 years in research at MIT (Massachusetts Institute of Technology), evaluating various magnesium compounds and their ability to increase magnesium levels in the brain.

  Different magnesium compounds vary significantly in their bioavailability and thus their ability to increase synaptic plasticity, which leads to increased memory and cognitive function.

  Dr. Liu reviews the biochemistry and signaling mechanisms that led to this new development in cognitive function and the effect of magnesium L-threonate on Alzheimer's disease in animal models, as well as a recent study assessing magnesium levels in Alzheimer's patients.

  

  Dr. Liu also helped develop Magtein and the magnesium molecule L-threonate. Magnesium L-threonate shows promising potential in studies for:

  • increased magnesium levels in the brain
  • improvement of short-term and long-term memory
  • as well as improving spatial perception and cognitive function.

  Dr. Liu's tests show that magnesium L-threonate, after absorption, reaches the brain better than other forms of magnesium, and thus shows the best results.

  Dr. Liu is also working on a hypothesis showing a correlation between magnesium deficiency and the occurrence of Alzheimer's disease. According to his findings, patients with the disease have low magnesium levels.

Dr. Mercola Magnesium Threonate 90 capsules - Ingredients:

3 vegan capsules (2000 mg magnesium L-threonate) contain approximately 144 mg of essential magnesium

Magnesium L-threonate, microcrystalline and hydroxypropyl cellulose, ascorbyl palmitate (vitamin C), capsule (hyroxypropylmethyl cellulose)

Dosage: 3 capsules daily, 2 hours before bedtime, 2 hours after meals or on an empty stomach.

Pack of 90 capsules for 30 days.

Notice:
This product was marketed as a dietary supplement. The product has no approved medicinal effects and is not a medicine. Does not serve as a substitute for a varied diet. Do not exceed the recommended dosage. Keep out of reach of children. Minimum shelf life indicated on the packaging. The information provided here is not intended to increase consumption and distribution of products. We do not encourage you to make inappropriate, immoderate or unjustified use of the products. Always carefully read the package leaflet, active ingredients and consult your doctor or pharmacist about the use of the products.