Mannose and its synergistic function with cranberry extract

Mannose and cranberry extract are valued for supporting urinary tract activity, as both substances effectively help maintain optimal function and cleanliness of the urinary tract. These natural ingredients support proper balance and function of the urinary system. Additionally, mannose and cranberries are not known to have bacterial resistance, making them a safe choice for long-term use.

What is mannose?

Mannose is a simple sugar that occurs naturally in several fruits and vegetables, including apples, oranges, and broccoli. Unlike other sugars, mannose is metabolized slowly in the body, does not raise blood sugar levels, and most of it passes into the urinary tract. There, it plays the role of "bait" - microbes in the urinary system look for human cells, which they commonly attach to and colonize the tract. Instead of attaching to these cells and subsequently to the urinary wall, microbes attach to mannose and are excreted with it in the urine.

Cranberry extract for urinary tract function

Cranberry extract is another well-known natural remedy for supporting urinary tract function. We used cranberry extract standardized to 10% proanthocyanidins (PACs), which support normal urinary tract function by blocking the adhesion of microbes to the walls of the urinary tract. When mannose and cranberry extract are combined, their effects may be synergistically enhanced.

Why can urinary tract problems occur?

Problems with the urinary tract can occur due to insufficient fluid intake. This can cause urine to become more concentrated, making it easier for microbes to multiply and survive. Some reasons that may cause problems:

• Insufficient fluid intake: low fluid intake means less urination, which allows microbes to linger in the urinary tract longer.
• Urinary retention: postponing a visit to the toilet can lead to an overgrowth of microbes in the bladder.
• Insufficient hygiene
• Using irritating products: soaps, hygiene sprays or deodorants in the genital area can irritate the urinary tract.
• Insufficient intake of vitamins and minerals: weak immunity caused by poor nutrition can make it difficult for the body to defend itself.

Backed by studies!

Kyriakides, R., Jones, P., & Somani, B. (2020). Role of D-Mannose in the Prevention of Recurrent Urinary Tract Infections: Evidence from a Systematic Review of the Literature.. European urology focus.

Lenger, S., Bradley, M., Thomas, D., Bertolet, M., Lowder, J., & Sutcliffe, S. (2020). D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis.. American journal of obstetrics and gynecology.

Franssen, M., Cook, J., Robinson, J., Williams, N., Glogowska, M., Yang, Y., Allen, J., Butler, C., Thomas, N., Hay, A., Moore, M., & Hayward, G. (2019). D-MannosE to prevent Recurrent urinary tract infections (MERIT): protocol for a randomized controlled trial. BMJ Open, 11.